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Opioid exercise is due to equally low affinity binding of the parent compound and better affinity binding on the O-demethylated metabolite M1 to µ-opioid receptors. In animal designs, M1 is nearly 6 occasions extra potent than tramadol in making analgesia and 200 instances far more strong in µ-opioid binding. Ukoliko https://mattz455gyp6.dekaronwiki.com/user

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