Lifestyle-threatening respiratory melancholy and death have transpired in young children who obtained codeine. Most of the documented scenarios happened following tonsillectomy and/or adenoidectomy and plenty of of the kids experienced proof of remaining ultra-immediate metabolizers of codeine as a result of a cytochrome P450 (CYP) 2D6 polymorphism (see WARNINGS, Safeguards; https://wockusa.com/product-category/codeine/