And finally, clonidine enhances neuraxial opioids and, in combination with fentanyl, interacts in an additive method, which may reduce the dose of each ingredient by 60% for postoperative analgesia. For people who get dizzy when standing: This affliction is known as orthostatic hypotension. Clonidine will make this ailment worse. https://www.proleviate.com/post/the-new-pain-killer-conolidine